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Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation
Published on: October 4, 2024
Elucidating Allosteric Communications in Proteins with Difference Contact Network Analysis
Xin-Qiu Yao1, Mohamed Momin1, Donald Hamelberg1
1Department of Chemistry , Georgia State University , Atlanta , Georgia 30302-3965 , United States.
Abstract:
A difference contact network analysis (dCNA) method is developed for delineating allosteric mechanisms in proteins. The new method addresses limitations of conventional network analysis methods and is particularly suitable for allosteric systems undergoing large-amplitude conformational changes during function. Tests show that dCNA works well for proteins of varying sizes and functions. The design of dCNA is general enough to facilitate analyses of diverse dynamic data generated by molecular dynamics, crystallography, or nuclear magnetic resonance.
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