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Testing for behavioral effects of agents.

P B Dews¹, G R Wenger

¹Laboratory of Psychobiology, Harvard Medical School, Boston, MA 02115.

Neurobehavioral Toxicology

|January 1, 1979

Summary

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Behavioral toxicology is crucial as chemical exposures can alter behavior before physical signs appear. Detecting subtle behavioral changes in toxicology studies is challenging, necessitating complementary research methods.

Area of Science:

Neuroscience
Toxicology
Behavioral Science

Background:

Schizophrenia and other conditions demonstrate profound behavioral disturbances without detectable morphological or chemical changes.
Exogenetic intoxication is hypothesized to cause behavioral changes that are not yet identifiable through traditional toxicological markers.

Purpose of the Study:

To highlight the necessity of studying behavioral toxicology.
To illustrate the limitations of experimental behavioral toxicology using a behavioral teratology study in mice.

Main Methods:

An experiment on behavioral teratology in mice was conducted.
Analysis of reported and observed variability in behavioral toxicology.

Main Results:

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Behavioral changes, unlike lethality or carcinogenicity, are quantitative and variable.

Experimental methods may fail to detect subtle behavioral impairments (e.g., 1% population incidence or 10% decrement).

Conclusions:

Behavioral toxicology is essential for understanding chemical impacts on health.
Epidemiological studies are vital to supplement experimental toxicology for assessing risks of subtle behavioral impairments and rare susceptibilities.