Related Experiment Video
Updated: Feb 8, 2026

Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis
Published on: November 14, 2016
Progressive visual function impairment as the predominant symptom of the transition phase to secondary progressive
A Giordano1, B Colombo1, E G Spinelli1
1San Raffaele Scientific Institute and University Hospital, Department of Neurology, Milan, Italy.
Background:
No reliable indicators of the transition to the progressive course in multiple sclerosis (MS) have been identified so far. The main clinical feature of the progressive phase of MS is usually impairment of walking. Magnetic resonance imaging and optical coherence tomography have emerged recently as promising tools to assess increasing neurodegeneration and axonal loss in disease progression in MS.
Results:
We report a case of progressive visual impairment as the dominant symptom in the transition to secondary progressive MS.
Conclusions:
Impairment of vision, together with walking and cognition, should be considered to better define the transition from relapsing/remitting to secondary-progressive MS.
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