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Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model
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Aripiprazole and pregnancy: A retrospective, multicentre study.
Megan Galbally1, Jacquie Frayne2, Stuart J Watson3
1School of Psychology and Exercise Science, Murdoch University, Australia; School of Medicine, University of Notre Dame, Australia; King Edward Memorial Hospital, Australia.
Journal of Affective Disorders
|June 30, 2018
Summary
Aripiprazole use during pregnancy did not increase gestational diabetes risk but was linked to higher rates of pregnancy hypertension and neonatal complications. Further research is needed to confirm these findings in larger studies.
Area of Science:
- Perinatal psychiatry
- Pharmacology
- Maternal-fetal medicine
Background:
- Aripiprazole, a second-generation antipsychotic, has a favorable metabolic and sedation profile.
- Pregnancy carries risks for metabolic complications like gestational diabetes and postpartum sedation concerns.
- Limited data exists on aripiprazole safety during pregnancy, particularly regarding neonatal outcomes.
Purpose of the Study:
- To assess the safety and pregnancy outcomes associated with aripiprazole use during pregnancy.
- To investigate potential risks of aripiprazole in pregnant women with severe mental illness.
Main Methods:
- Preliminary data collected from 26 women using aripiprazole during pregnancy.
- Participants attended antenatal clinics for severe mental illness at two Australian hospitals.
Main Results:
- Aripiprazole use was not associated with an increased risk of gestational diabetes.
- Associated with increased risks of pregnancy hypertension, lower birth weight, and shorter gestation.
- Higher neonatal admission rates were observed in infants exposed to aripiprazole.
Conclusions:
- Aripiprazole appears unlikely to pose a significant metabolic risk during pregnancy.
- Further investigation is required to confirm associations with pregnancy hypertension and neonatal complications.
- Larger, well-designed studies are necessary to validate these preliminary findings and address potential confounding factors.
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