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Published on: January 19, 2024
Micronutrient Fortification at Child-Care Centers Reduces Anemia in Young Children
Francisco Plácido Nogueira Arcanjo1, Thaís Cristina da Costa Rocha1, Caio Plácido Costa Arcanjo2
1Department of Master's Degree in Family Health, Federal University of Ceará , Sobral , Brazil.
Insights
NutriSUS micronutrient fortification effectively improved hemoglobin levels and reduced anemia prevalence in infants aged 12-36 months. Further large-scale studies are needed to confirm these beneficial effects.
Area of Science:
- Public Health
- Pediatrics
- Nutrition Science
Background:
- Iron deficiency anemia is a significant global health concern in infants and young children.
- Early nutritional interventions are crucial for preventing and treating anemia in this vulnerable population.
Purpose of the Study:
- To assess the efficacy of NutriSUS micronutrient fortification for preventing and treating iron deficiency anemia in infants aged 12-36 months.
- To evaluate changes in hemoglobin concentration and anemia prevalence following a 12-week intervention.
Main Methods:
- A cluster-randomized clinical trial involving infants aged 12-36 months in Northeast Brazil.
- Participants were randomized into two groups: NutriSUS micronutrient fortification (Group A) or a control group (Group B).
- Hemoglobin levels and anemia prevalence were measured before and after the 12-week intervention period.
Main Results:
- Group A (NutriSUS) showed a statistically significant increase in mean hemoglobin concentration (11.4 to 11.9 g/dL, p = .006).
- In Group A, 15 out of 20 anemic infants normalized their hemoglobin levels, with a Number Needed to Treat of 2.
- Group B (control) showed no significant change in hemoglobin levels, and most anemic infants remained anemic.
Conclusions:
- NutriSUS micronutrient fortification demonstrated a beneficial effect on hemoglobin values and reduced anemia prevalence in the studied infant population.
- The findings suggest NutriSUS is a promising intervention for managing iron deficiency anemia in young children.
- Further large-scale research is recommended to validate the effectiveness of NutriSUS in diverse populations.
Abstract:
The aim of this study was to evaluate the effectiveness of NutriSUS micronutrient fortification, in infants aged 12-36 months, for the prophylaxis and treatment of iron deficiency anemia. In this cluster-randomized clinical trial study, we evaluated infants aged 12-36 months. Length of intervention was 12 weeks. Children were cluster randomized to either NutriSUS micronutrient fortification (Group A) or control (Group B). Primary outcome variables were change in hemoglobin concentration and anemia prevalence. Two biochemical evaluations were performed to determine hemoglobin concentrations: before and after intervention. This study was conducted in eight child-care centers located within the urban perimeter of the municipality of Sobral, Ceará, in the northeast of Brazil. For Group A, baseline mean hemoglobin concentration was 11.4 ± 1.01 g/dL; after intervention it was 11.9 ± 0.90 g/dL (p = .006); 15 of 20 participants who were anemic at baseline had normal Hb levels after intervention. Number needed to treat = 2. In group B, mean baseline hemoglobin was 11.9 ± 0.89 g/dL; after intervention it was 12.2 ± 0.92 g/dL (p = .58); 4 of 5 participants who were anemic at baseline remained anemic after intervention. In our study, NutriSUS micronutrient fortification provided a beneficial effect on Hb values, reducing the prevalence of anemia. However, further studies are necessary to confirm the effectiveness of this intervention in populations on a larger scale.
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