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Updated: Feb 8, 2026

In vivo Measurement of Knee Extensor Muscle Function in Mice
Published on: March 4, 2021
How does patellar tendon advancement alter the knee extensor mechanism in children treated for crouch gait?
Moria F Bittmann1, Rachel L Lenhart1, Michael H Schwartz2
1Department of Mechanical Engineering, University of Wisconsin-Madison, USA.
Background:
The patellar tendon advancement (PTA) procedure, often coupled with a distal femoral extension osteotomy (DFEO), is increasingly used to treat persistent crouch gait. In this study, we investigated relationships between patella position, knee flexion, and the patellar tendon moment arm in children treated with the DFEO and PTA procedures.
Methods:
We retrospectively analyzed pre- and post-operative radiographs and gait metrics from 63 knees that underwent DFEO and PTA procedures at Gillette Children's Specialty Healthcare. A computational musculoskeletal model of the knee was used to simulate the PTA procedure and predict the effects on the patellar tendon moment arm.
Results:
Approximately 80% of the knees exhibited patella alta prior to surgery. Post-operatively, 86% of the knees exhibited patella baja. The surgically altered patella position produced a 13% increase in the patellar tendon moment arm in extended knee postures, which agreed well with model predictions. However, the computational model also suggests that baja may compromise patellar tendon moment arms in flexed knee postures. Crouch gait was significantly reduced postoperatively, with a 27 ± 18° reduction in average knee flexion in stance. There was considerable inter-subject variability in outcomes with nine knees not exhibiting a meaningful enhancement of knee extension (<15° change). The subjects who improved were significantly younger and exhibited greater enhancement of the patellar tendon moment arm after surgery.
Conclusions:
This study shows that the PTA procedure enhances the lever arm of the knee extensor mechanism, and this factor may be important in resolving crouch gait.
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Overview of Advanced Functional Groups
Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
Extraction: Advanced Methods

