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Updated: Feb 8, 2026

Murine Model of Wound Healing
Published on: May 28, 2013
A revisited concept. Tumors: Wounds that do not heal
Domenico Ribatti1, Roberto Tamma1
1Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, National Cancer Institute "Giovanni Paolo II", Bari, Italy.
Abstract:
In 1986, Harold F. Dvorak, Professor of Pathology at Harvard Medical School Boston, published an essay in the New England Journal of Medicine entitled "Tumors: Wounds that do not heal" pointed out that similarities exist between tumor stroma generation and wound healing. Cancers share many features in common with tissue regeneration, including immune response, cell proliferation, cell migration, tissue remodeling, and cell death. In this review article, we analyze the importance and the limits of this concept, which confirm the close relationship between two apparently different biological processes.
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