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Related Experiment Video

Updated: Feb 8, 2026

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

[Bilateral uveitis associated with nivolumab therapy].

A-L Rémond¹, E Barreau², P Le Hoang¹

¹Hôpital Pitié-Salpêtrière, 47-83, boulevard de l'hôpital, 75013 Paris, France.

Journal Francais D'Ophtalmologie

|July 1, 2018

Summary

Immune-related adverse events (IRAEs) can occur with immune checkpoint inhibitors like nivolumab. This case highlights an inflammatory ocular disease potentially linked to nivolumab treatment, emphasizing careful benefit-risk assessment and multidisciplinary collaboration for management.

Keywords:

Anti-PD1 Check point inhibitors Chemotherapy Chirurgie de la cataracte Drug induced uveitis Dysfonctionnement meibomien Expressibilité meibomienne Meibographie Nivolumab Posterior uveitis Sécheresse oculaire Uveitis

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Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Published on: January 12, 2022

Area of Science:

Oncology
Immunology
Ophthalmology

Background:

Immune-related adverse events (IRAEs) are uncommon but severe side effects associated with immune checkpoint inhibitors.
Nivolumab is an emerging immunotherapy used for solid tumor treatment.

Observation:

A case of inflammatory ocular disease potentially associated with nivolumab treatment is presented.
The temporal relationship suggests a possible link between nivolumab and the onset of ocular inflammation.
Differential diagnosis is crucial, as other causes of ocular inflammation must be excluded.

Findings:

Nivolumab therapy may trigger immune-related adverse events affecting the eye.
Management requires a careful balance of treatment benefits against potential risks.
Continued nivolumab treatment may be feasible after risk-benefit evaluation.

Implications:

Close collaboration between oncologists and ophthalmologists is vital for timely diagnosis and management.
Prompt recognition and treatment of ocular IRAEs can prevent severe visual impairment.
Understanding these IRAEs is crucial for the safe application of novel immunotherapies.