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Updated: Feb 8, 2026

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
Published on: August 28, 2018
Preptin is a new predictor of coronary artery calcification
Bo Li1, Yuhua Li2, Tongtong Zhang3
1Department of Cardiology, Central Hospital of Zibo, NO, 54, Gong Qing Tuan Xi Road, Zibo 255036, PR China.
Background:
We aimed to assess whether an elevated preptin level is associated with coronary artery calcification (CAC).
Methods:
Two hundred and twenty participants with suspected cardiovascular disease were recruited. CAC was measured using 320-row-detector dynamic volume CT, and the patients were divided into 2 groups: the non-CAC group (with an Agatston score = 0) and the CAC group (with an Agatston score > 0).
Results:
The serum preptin level was significantly elevated in the CAC group compared with the non-CAC group. In logistic regression analysis, preptin, as well as age, gender, hypertension history and history of β-blocker use, were independent predictors of a positive CAC score. The highest preptin quintile of patients had a higher CAC level compared with other quintiles. Binary logistic regression analyses showed that the highest preptin quintile had a 2.9-time increased odds ratio of an elevated CAC level than the other 4 quintile patients.
Conclusions:
This study demonstrated that serum preptin was associated with coronary artery calcification.
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