Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

33.9K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.9K
Epigenetic Regulation01:37

Epigenetic Regulation

3.9K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.9K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

7.1K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
7.1K
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

7.0K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
7.0K
Energy Basics02:27

Energy Basics

47.8K
Chemical reactions, such as those that occur when you light a match, involve changes in energy as well as matter.
47.8K
Basicity of Aliphatic Amines01:21

Basicity of Aliphatic Amines

6.9K
Amines can behave as Brønsted–Lowry bases by accepting a proton from the acid to form corresponding conjugate acids. Due to a lone pair of nonbonding electrons, aliphatic amines can also act as Lewis bases by forming a covalent bond with an electrophile.
To measure the basicity of amines, two conventions are generally used. The first defines Kb as the basicity constant for the deprotonation reaction of water by the amine, as presented in Figure 1. Conventionally, lower Kb indicates higher...
6.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

HLA Class I Expression is Associated with Increased Immune Cell Density and PTEN Loss in Prostate Cancer.

Molecular cancer research : MCR·2026
Same author

Evaluation of Tissue from Patients with Prostate Cancer Identifies B7-H3 as an Androgen-Regulated, Broadly-Expressed, Combinatorial Therapeutic Target.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

Castration Resistance Accelerates Prostate Cancer Kinetics.

The Prostate·2026
Same author

The molecular pathology of prostate cancer: an update for practising pathologists.

Histopathology·2026
Same author

Subclonal Complete Loss of <i>CDKN1B</i> as a Common Genomic Alteration in Prostate Cancer: Associations with Race and Prostate Cancer Outcomes.

bioRxiv : the preprint server for biology·2026
Same author

Divergent effects of PLA2G7 on prostate cancer biochemical recurrence in European American and African American men.

Journal of the National Cancer Institute·2026

Related Experiment Video

Updated: Feb 8, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

11.3K

Prostate Cancer Epigenetics: From Basic Mechanisms to Clinical Implications.

Srinivasan Yegnasubramanian1, Angelo M De Marzo1, William G Nelson1

  • 1Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21231.

Cold Spring Harbor Perspectives in Medicine
|July 1, 2018
PubMed
Summary

Epigenetic programming, the "epigenetic cityscape," is crucial for cell identity and function. Alterations in this cityscape, alongside genetic changes, drive prostate cancer, offering potential biomarker and therapeutic targets.

More Related Videos

Pre-clinical Orthotopic Murine Model of Human Prostate Cancer
07:01

Pre-clinical Orthotopic Murine Model of Human Prostate Cancer

Published on: August 29, 2016

15.0K
Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
07:16

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Published on: March 14, 2014

14.6K

Related Experiment Videos

Last Updated: Feb 8, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

11.3K
Pre-clinical Orthotopic Murine Model of Human Prostate Cancer
07:01

Pre-clinical Orthotopic Murine Model of Human Prostate Cancer

Published on: August 29, 2016

15.0K
Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
07:16

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Published on: March 14, 2014

14.6K

Area of Science:

  • Genomic regulation and epigenetics
  • Cancer biology and molecular oncology

Background:

  • Epigenetic programming, involving DNA/histone modifications and interactions, governs genome structure and function.
  • This epigenetic landscape is critical for establishing normal and neoplastic cell identities.
  • The interplay between genetic and epigenetic alterations drives prostate cancer initiation and progression.

Purpose of the Study:

  • To explore the role of the "epigenetic cityscape" in prostate cancer.
  • To investigate the relationship between genetic and epigenetic alterations in prostate cancer development.
  • To identify potential therapeutic targets and biomarkers based on epigenetic changes.

Main Methods:

  • Analysis of epigenetic modifications in prostate cancer cells and normal tissues.
  • Comparison of the "epigenetic cityscape" between normal and cancerous prostate tissues.
  • Investigation of mutations in genes encoding epigenetic enzymes in prostate cancer.

Main Results:

  • Significant alterations in the epigenetic cityscape of prostate cancer cells compared to normal tissues.
  • Evidence of a complex interplay between genetic and epigenetic changes in driving prostate cancer.
  • Recurrent alterations in the prostate cancer epigenetic cityscape were observed.

Conclusions:

  • Epigenetic programming is fundamental to prostate cancer cell identity and function.
  • Altered epigenetic landscapes, alongside genetic mutations, are key drivers of prostate cancer.
  • Recurrent epigenetic alterations present opportunities for developing novel biomarkers and therapies for prostate cancer.