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Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging
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Pathology, Chemoprevention, and Preclinical Models for Target Validation in Barrett Esophagus

Aleksandra M Urbanska1, Selvarangan Ponnazhagan2, Masoud Mozafari3,4,5

  • 1Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, New York.

Cancer Research
|July 1, 2018
PubMed

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Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
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Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
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