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Updated: Feb 8, 2026

Diagnosing Pulmonary Tuberculosis with the Xpert MTB/RIF Test
Published on: April 9, 2012
Tuberculous arthritis: negative Xpert MTB/RIF assay does not rule out infection!
Rebecca Davis1, Clare Higgens1, Catherine Cosgrove1
1Infectious Diseases, St George's University Hospital NHS Foundation Trust, London, UK.
Abstract:
We present a case of a 31-year-old man of Indian origin with no previous medical history who presented with an inflamed knee. Treatment for bacterial infection was unsuccessful, and needle aspiration of the left knee effusion/collection was smear and culture positive for tuberculosis (TB), despite Xpert MTB/RIF being falsely negative. The patient was commenced on quadruple therapy for TB and within 2 months had improved significantly with no clinical evidence of ongoing inflammation.
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