Related Experiment Video
Updated: Feb 8, 2026
03:36
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
855
Prognostic New Marker (Bone Morphogenetic Protein 7) in Squamous Cell Carcinoma
Azadehzeinab Titidej1, Nosratollah Eshghyar2, Maryam Jolehar3
1Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Qazvin University of Medical Sciences, Qazvin, Islamic Republic of Iran.
The Journal of Contemporary Dental Practice
|July 1, 2018
Summary
Bone morphogenetic protein 7 (BMP7) expression is linked to poor outcomes in oral squamous cell carcinoma (OSCC). High BMP7 levels correlate with advanced tumor features, suggesting its potential as a prognostic marker for oral cancer.
Area of Science:
- Oncology
- Biomarkers
- Oral Cancer Research
Background:
- Oral squamous cell carcinoma (OSCC) treatment advances have not significantly improved patient prognosis.
- Identifying reliable prognostic factors is crucial for effective OSCC management.
Purpose of the Study:
- To investigate the expression level of bone morphogenetic protein 7 (BMP7) in tongue SCC.
- To determine the relationship between BMP7 expression and clinicopathologic parameters in OSCC.
Main Methods:
- Cross-sectional study involving 128 primary OSCC patients.
- Immunohistochemistry staining for BMP7 detection on retrieved tissue samples.
- Statistical analysis using chi-square and logistic regression tests.
Main Results:
- Elevated BMP7 expression was observed in men (54%), younger patients (<45 years, 70%), and those with lymph node metastasis (68.2%).
- 100% of poorly differentiated tumors showed high BMP7 expression.
- Multivariate analysis indicated lymph node metastasis and higher histopathological grade significantly increased BMP7 expression odds.
Conclusions:
- BMP7 expression is significantly associated with poor cellular differentiation and lymph node metastasis in OSCC.
- BMP7 may serve as a novel prognostic marker for oral cancer.
- This marker could aid clinicians in predicting oral cancer prognosis and optimizing treatment strategies.
Related Concept Videos
01:30Bone Cells and Tissue
8.4K
Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
8.4K
02:50Conjugated Proteins
28.9K
Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
28.9K
01:55Bone Structure
51.8K
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
51.8K
01:40Bone Remodeling
40.5K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.5K
01:27Compact Bone
16.6K
Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
16.6K
01:29Bone Disorders
5.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.4K