Related Experiment Video
Updated: Jul 13, 2026
07:03
Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
Published on: July 31, 2019
Motion-induced position shift in early Alzheimer's disease
1Department of Neurology, The Central Hospital of Wuhan Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan City, 430014, China. fei.ye1@hotmail.com.
Scientific Reports
|July 1, 2018
Summary
Alzheimer's disease (AD) patients showed reduced susceptibility to the motion-induced position shift illusion. This finding suggests a potential new behavioral indicator for early AD identification.
Area of Science:
- Neuroscience
- Perceptual Psychology
- Ophthalmology
Background:
- Accurate object position localization is crucial for human visual abilities.
- Motion-induced position shift is a perceptual illusion where object position is misperceived along the direction of motion.
- Understanding how neurological conditions affect visual perception is vital for diagnosis and treatment.
Purpose of the Study:
- To investigate the impact of early Alzheimer's disease (AD) on the motion-induced position shift illusion.
- To determine if AD patients exhibit altered perception of motion-induced position shifts compared to healthy controls.
Main Methods:
- Recruited early Alzheimer's disease (AD) patients and age-matched healthy controls.
- Presented participants with two oppositely drifting Gabor patches.
- Measured psychometric functions to quantify the motion-induced position shift magnitude at different retinal eccentricities.
Main Results:
- Alzheimer's disease (AD) patients exhibited significantly smaller motion-induced position shifts compared to healthy controls.
- The magnitude of the position shift was reduced in the AD group across all tested eccentricities.
- Data indicate that AD patients are less susceptible to this specific visual illusion.
Conclusions:
- Early Alzheimer's disease (AD) demonstrably alters the perception of motion-induced position shifts.
- The reduced susceptibility to this illusion in AD patients highlights a specific perceptual deficit.
- Motion-induced position shift may serve as a novel and effective behavioral biomarker for early Alzheimer's disease (AD) detection.
Related Concept Videos
01:26Alzheimer's Disease: Overview
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
01:22Alzheimer's Disease: Treatment
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
01:29Alzheimer Disease l: Introduction
Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
01:23Alzheimer Disease ll: Pathophysiology
Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...
01:24Parkinson Disease ll: Pathophysiology
Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
01:11Alterations in Muscle Tone lll
Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...