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Assessment of Kidney Function in Mouse Models of Glomerular Disease
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The role of B7-1 in proteinuria of glomerular origin

Rubina Novelli1, Ariela Benigni1, Giuseppe Remuzzi2,3,4

  • 1IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, Italy.

Nature Reviews. Nephrology
|July 1, 2018
PubMed

Insights

B7-1 (CD80) is a potential biomarker for nephrotic syndrome. Further research is needed to standardize methods for B7-1 blockade therapy, which is currently in clinical trials for treatment-resistant cases.

Area of Science:

  • Nephrology
  • Immunology
  • Pathophysiology

Background:

  • Podocyte damage and loss are key features of nephrotic syndrome.
  • B7-1 (CD80) has been identified as a potential biomarker in podocyte pathophysiology.
  • B7-1 blockade is a proposed podocyte-specific treatment for various nephrotic syndromes.

Purpose of the Study:

  • To review and compare evidence supporting and refuting the role of podocyte B7-1 in podocytopathies.
  • To highlight critical issues for standardization in immunohistochemical protocols.
  • To inform ongoing clinical trials on B7-1 blockade efficacy.

Main Methods:

  • Literature review and comparison of supporting and contradicting data.
  • Analysis of B7-1's role in focal segmental glomerulosclerosis, minimal change disease, diabetic nephropathy, and lupus nephritis.
  • Identification of critical factors for clinical trial standardization.

Main Results:

  • Conflicting data exists regarding the precise role of podocyte B7-1 in disease pathogenesis.
  • Standardization of sample processing, material conservation, and antibody usage is crucial.
  • A clinical trial is underway to evaluate B7-1 blockade in treatment-resistant nephrotic syndrome.

Conclusions:

  • The role of podocyte B7-1 in nephrotic syndrome requires further clarification.
  • Standardized protocols are essential for reliable B7-1 assessment and therapeutic development.
  • B7-1 blockade holds promise as a targeted therapy for specific nephrotic conditions.

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