Related Experiment Video
Updated: Feb 8, 2026
23:53
Ole Isacson: Development of New Therapies for Parkinson's Disease
Published on: April 29, 2007
8.4K
The multisystemic functions of FOXD1 in development and disease
Paula Quintero-Ronderos1, Paul Laissue2
1Center For Research in Genetics and Genomics-CIGGUR, GENIUROS Research Group, School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 No. 63C-69, Bogotá, Colombia.
Journal of Molecular Medicine (Berlin, Germany)
|July 1, 2018
Summary
Forkhead box D1 (FOXD1) is a crucial transcription factor involved in development and disease. This review details FOXD1
Area of Science:
- Developmental Biology
- Molecular Biology
- Genetics
Background:
- Transcription factors (TFs) regulate cellular processes; their dysfunction causes disease.
- The forkhead box (FOX) TF family is vital in evolution and biological functions.
- FOXD1 is implicated in development and disease, serving as a biomarker and therapeutic target.
Purpose of the Study:
- To comprehensively review the role of FOXD1 in mouse development and human disease.
- To present molecular, structural, and functional aspects of FOXD1 in physiological and pathological contexts.
Main Methods:
- Literature review and synthesis of existing research on FOXD1.
- Analysis of FOXD1's involvement in developmental processes and disease etiology.
Main Results:
- FOXD1 plays key roles in kidney and retina development and embryo implantation.
- FOXD1 dysfunction is linked to pathologies including cancer and recurrent pregnancy loss.
Conclusions:
- FOXD1 is critical for normal development and its dysregulation contributes to human diseases.
- Understanding FOXD1 is essential for researchers and clinicians for diagnostic and therapeutic advancements.
Related Concept Videos
01:58Fruit Development, Structure, and Function
25.4K
Fruits form from a mature flower ovary. As seeds develop from the ovules contained within, the ovary wall undergoes a series of complex changes to form fruit. In some fruits, such as soybeans, the ovary wall dries; in other fruits, such as grapes, it remains fleshy. In some cases, organs other than the ovary contribute to fruit formation; such fruits are called accessory fruits.
25.4K
01:22Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
207
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
207
01:43Sustainable Development
15.2K
As the human population continues to grow and use resources, we must be mindful of our planet’s natural limits. Sustainable development provides a pathway to maintain and improve human life now while also ensuring that future generations will have the resources that they need. The long-term success of sustainability efforts rests on understanding the interplay between human actions and ecological systems.
15.2K
02:45Functional Groups
89.1K
Functional groups are a group of atoms with characteristic properties, which when linked to the carbon skeleton of a molecule, alter the properties of that molecule. For example, the presence of certain functional groups on a molecule will make them hydrophilic, whereas others will make them hydrophobic. These functional groups are an indispensable part of organic chemistry and important components of biological molecules, such as carbohydrates, proteins, lipids, and nucleic acids. Each...
89.1K
01:30Inflammatory Bowel Disease II: Crohn's Disease
1.1K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.1K
01:56Structural Protein Function
30.0K
Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to...
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to...
30.0K