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Updated: Feb 8, 2026
05:53
The Generation of Closed Femoral Fractures in Mice: A Model to Study Bone Healing
Published on: August 16, 2018
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FGF23-klotho axis, bone fractures, and arterial stiffness in dialysis: a case-control study
L-C Desbiens1,2, A Sidibé1,3, R-V Ung1
1CHU de Québec Research Center, Endocrinology and Nephrology Axis, Quebec, Canada.
Summary
Fibroblast growth factor-23 (FGF23) levels are linked to increased fracture risk in hemodialysis patients. Soluble α-klotho levels correlate with arterial stiffness, suggesting a role in bone and vascular health.
Area of Science:
- Nephrology
- Endocrinology
- Bone Metabolism
Background:
- Chronic kidney disease (CKD) is associated with bone and vascular abnormalities.
- Novel bone markers including sclerostin, Dickkopf-related protein 1 (DKK1), fibroblast growth factor-23 (FGF23), and α-klotho are implicated in CKD complications.
Purpose of the Study:
- To investigate the association of FGF23, α-klotho, sclerostin, and DKK1 with fractures, bone metabolism, and vascular stiffness in hemodialysis patients.
Main Methods:
- A case-control study involving 130 hemodialysis patients (26 fractured, 104 non-fractured) matched for age and sex.
- Baseline plasma levels of FGF23, α-klotho, sclerostin, DKK1, bone formation markers (alkaline phosphatase, P1NP), and bone resorption markers (TRAP5b) were measured.
- Aortic-brachial pulse wave velocity ratio was used to assess arterial stiffness.
Main Results:
- High FGF23 levels were significantly associated with an increased incidence of fractures (adjusted HR = 2.97).
- α-Klotho levels correlated with bone formation markers but not resorption markers.
- Lower α-klotho levels were inversely associated with aortic-brachial arterial stiffness (β = -0.070).
Conclusions:
- The FGF23/klotho axis plays a role in regulating bone and vascular metabolism in patients undergoing hemodialysis.
- These findings highlight potential therapeutic targets for managing bone and vascular complications in CKD.
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