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Updated: Feb 8, 2026
09:24
3-D Cell Culture System for Studying Invasion and Evaluating Therapeutics in Bladder Cancer
Published on: September 13, 2018
9.5K
Bladder Preserving Trimodality Therapy for Muscle-Invasive Bladder Cancer
Skyler B Johnson1, James B Yu2,3
1Department of Therapeutic Radiology, Yale School of Medicine, HRT 138, 333 Cedar St, New Haven, CT, 06520, USA.
Current Oncology Reports
|July 1, 2018
Summary
Bladder preserving trimodality therapy offers an alternative to cystectomy for muscle-invasive bladder cancer, showing comparable oncologic outcomes and satisfactory quality of life in select patients.
Area of Science:
- Uro-oncology
- Surgical oncology
- Radiation oncology
Background:
- Muscle-invasive bladder cancer (MIBC) traditionally requires radical cystectomy.
- Radical cystectomy involves significant morbidity and impacts quality of life.
- Bladder preservation strategies are sought to improve patient outcomes.
Purpose of the Study:
- To review current data on trimodality therapy (TMT) for MIBC.
- To evaluate TMT as an alternative to cystectomy.
- To summarize emerging evidence on bladder preservation in MIBC.
Main Methods:
- Review of current literature and emerging data on TMT for MIBC.
- Analysis of observational data comparing TMT with radical cystectomy.
- Focus on oncologic and functional outcomes, and quality of life.
Main Results:
- No randomized-controlled trials directly compare radical cystectomy with TMT.
- Observational data indicate acceptable bladder preservation and functional outcomes with TMT.
- Oncologic outcomes with TMT appear similar to radical cystectomy in select MIBC patients.
- TMT demonstrates satisfactory quality of life for eligible patients.
Conclusions:
- Bladder preserving trimodality therapy is a viable alternative to cystectomy for select MIBC patients.
- TMT offers comparable oncologic outcomes and improved quality of life.
- Future research will explore novel techniques and therapeutics in bladder cancer treatment.
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