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Updated: Feb 8, 2026
05:59
Reproducable Paraplegia by Thoracic Aortic Occlusion in a Murine Model of Spinal Cord Ischemia-reperfusion
Published on: March 3, 2014
12.5K
Paraplegia as a presentation of primary hyperoxaluria
Yannick Dieudonné1, Laure Eprinchard1, Emilie Léon1
1Nephrology Department, CH Haguenau, 67500, Haguenau, France.
CEN Case Reports
|July 1, 2018
Summary
Primary hyperoxaluria type 1 is often diagnosed late, at end-stage renal disease. This case highlights calcium oxalate deposits causing spinal cord compression in a patient with undiagnosed hyperoxaluria.
Area of Science:
- Nephrology
- Oncology
- Neurology
Background:
- Primary hyperoxaluria type 1 (PH1) is a rare genetic disorder.
- Delayed diagnosis of PH1 frequently leads to end-stage renal disease (ESRD).
Observation:
- A 57-year-old woman with chronic kidney failure presented with paraplegia.
- Thoracic mass-like lesions causing spinal cord compression were identified.
- Bone biopsy revealed calcium oxalate deposits, leading to PH1 diagnosis.
Findings:
- The patient's neurological symptoms were attributed to calcium oxalate deposition.
- Hemodialysis provided incomplete recovery of neurological function.
- The patient was listed for kidney transplantation.
Implications:
- This case underscores the importance of considering PH1 in patients with unexplained kidney failure and neurological complications.
- Early diagnosis and intervention are crucial for managing PH1 and preventing severe complications.
- Calcium oxalate deposition can manifest in diverse ways, including spinal cord compression.
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