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Updated: Feb 8, 2026

Frailty Assessment in an Aging Mouse Model
Published on: September 23, 2025
Approach to the development of a frailty index based on comprehensive geriatric assessment in nursing home
Juan Francisco Peris-Martí1, Mª Ángeles Parro Martín2, Elia Fernández-Villalba3
1Servicio de Farmacia, RPMD La Cañada, Valencia. peris_jua@gva.es.
Objective:
To carry out an approach for the development of a frailty index in nursing homes and to analize its potential use in order to individualize the pharmacological treatment.
Method:
The frailty index was constructed from the information included in the comprehensive geriatric assessment established in nursing homes. The index has been retrospectively applied to the patients of two centers using the last comprehensive geriatric assessment of each one.
Results:
17 variables that included 27 deficits were selected and classified in 4 domains. 269 patients (mean age 82.9 ± 8.8 years) were included in the analysis. The frailty index indicated that 86% of patients should be considered frail and 60% of these to moderate-advanced level.
Conclusions:
The frailty index is simple and quick to apply. It seems to have discriminative capacity in terms of quantifying the degree of frailty and it could be useful in prescribing the most appropriate therapeutic aggressiveness to each patient.
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