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C.B-17 SCID mice develop epicardial calcinosis with unaltered cardiac function.

Suchi Raghunathan1, Corey L Reynolds2, Robert J Schwartz3

  • 1Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, 77204, TX, USA.

Fundamental & Clinical Pharmacology
|July 1, 2018
PubMed
Summary

C.B-17 SCID mice develop dystrophic cardiac calcinosis (DCC) by 10 weeks of age. This cardiac condition, characterized by myocardial injury and calcification, did not impact cardiac function in this mouse model.

Keywords:
SCIDcalcinosiscardiacepicardialheartmouse model

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Area of Science:

  • Biomedical research
  • Mammalian model organisms
  • Cardiovascular pathology

Background:

  • Inbred mouse strains are crucial for research due to genetic manipulability and short lifespans.
  • Each strain has unique genetic variations, potentially influencing disease susceptibility.
  • Understanding strain-specific pathologies is vital for accurate research outcomes.

Purpose of the Study:

  • To investigate the occurrence and characteristics of dystrophic cardiac calcinosis (DCC) in C.B-17 SCID mice.
  • To assess the impact of DCC on cardiac function in this specific mouse strain.
  • To determine the prevalence of DCC in C.B-17 SCID mice from different commercial sources.

Main Methods:

  • Histopathological examination of cardiac tissue to identify myocardial injury, fibrosis, calcification, and necrosis.
  • Echocardiography and electrocardiography to evaluate cardiac function.
  • Comparative analysis of DCC incidence across different commercial colonies of C.B-17 SCID mice.

Main Results:

  • Dystrophic cardiac calcinosis (DCC) was observed in 38% of C.B-17 SCID male mice at 10 weeks of age.
  • The condition manifested as myocardial injury, fibrosis, calcification, and necrosis, primarily on the right ventricle.
  • No significant differences in cardiac function, assessed by echocardiography and electrocardiography, were found between affected and unaffected mice.

Conclusions:

  • C.B-17 SCID mice develop DCC as early as 10 weeks of age.
  • The presence of DCC in these mice does not significantly alter cardiac function at this age.
  • Researchers should exercise caution when using C.B-17 SCID mice for cardiac physiology studies due to the potential for DCC.