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Updated: Feb 8, 2026

Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes
Published on: January 10, 2017
Carbon dots coated with molecularly imprinted polymers: A facile bioprobe for fluorescent determination of caffeic
Xiaoman Xu1, Guanhong Xu1, Fangdi Wei1
1School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu 211166, PR China.
Abstract:
A new and sensitive method for fluorescent determination of caffeic acid (CA) was proposed based on silane-functionazed carbon dots coated with molecularly imprinted polymers (CDs@MIPs). CDs@MIPs were prepared by using CA as the templates on the surface of silane-functionazed carbon dots(CDs) with a sol-gel process. The as-prepared CDs@MIPs were characterized by Fourier transform infrared spectroscopy, transmission electron microscopy and fluorescence spectroscopy. The CDs@MIPs exhibited distinguished selectivity and high binding affinity to CA templates, and also showed good reusability. Under optimal conditions, the fluorescence intensity of CDs@MIPs decreased linearly with the increase of CA in the range of 0.5-200 μM. The limit of detection was 0.11 μM (3σ/K). Finally, the proposed method was successfully applied to the detection of CA in human plasma. The result indicates that the method built has promising potential for monitoring CA concentration in clinic.
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