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Metabolic Changes of Brain Developmental Venous Anomalies on 18F-FDG-PET

Jillian W Lazor1, J Eric Schmitt1, Laurie A Loevner1

  • 1Department of Neuroradiology, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104.

Academic Radiology
|July 2, 2018
PubMed
Abstract

Insights

Developmental venous anomalies (DVAs) can alter brain metabolism, particularly in surrounding gray matter. These vascular lesions show abnormal physiological features detectable with 18F-FDG-PET imaging.

Area of Science:

  • Neuroradiology
  • Neuroimaging
  • Vascular Neurology

Background:

  • Developmental venous anomalies (DVAs) are common cerebral vascular malformations.
  • Their potential metabolic effects on surrounding brain tissue are not fully understood.

Purpose of the Study:

  • To investigate the metabolic consequences of DVAs.
  • To correlate metabolic findings with conventional magnetic resonance imaging (MRI) characteristics.

Main Methods:

  • Retrospective analysis of MRI and 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) scans in 54 subjects with 57 DVAs.
  • Assessed DVA characteristics (number, location, size) and parenchymal findings on MRI.
  • Evaluated qualitative and quantitative metabolism in DVA drainage territories using 18F-FDG-PET.

Main Results:

  • 38% of DVAs were associated with metabolic abnormalities on 18F-FDG-PET, primarily hypometabolism in adjacent parenchyma.
  • DVAs draining gray matter showed a higher likelihood of hypometabolism compared to those draining only white matter.
  • Findings suggest potential underestimation of metabolic effects by 18F-FDG-PET.

Conclusions:

  • Altered metabolism is frequently observed in the drainage territory of DVAs.
  • These findings support the classification of DVAs as vascular lesions with intrinsic abnormal physiological characteristics.
Keywords:
(18)F-FDG-PETbraindevelopmental venous anomalies

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