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Hepatitis C virus infection in chronic kidney disease: paradigm shift in management

So Mi Kim1, Il Han Song2

  • 1Division of Nephrology, Department of Internal Medicine, Dankook University Hospital, Cheonan, Korea.

The Korean Journal of Internal Medicine
|July 3, 2018
PubMed

Insights

Hepatitis C virus infection in chronic kidney disease patients significantly increases health risks. Newer direct-acting antiviral therapies offer effective treatment with fewer side effects compared to older methods.

Area of Science:

  • Nephrology
  • Hepatology
  • Infectious Diseases

Background:

  • Hepatitis C virus (HCV) infection complicates chronic kidney disease (CKD), increasing liver disease, end-stage renal disease, and cardiovascular risks.
  • Antiviral therapy is essential for HCV-infected CKD patients.
  • Previous standard treatment (pegylated interferon plus ribavirin) showed low efficacy and poor adherence.

Purpose of the Study:

  • To review the impact of HCV infection in CKD patients.
  • To discuss the management of HCV in CKD using novel direct-acting antiviral (DAA) regimens.

Main Methods:

  • Review of clinical trials and literature on HCV treatment in CKD patients.
  • Analysis of efficacy and safety data for direct-acting antiviral (DAA) combination therapies.

Main Results:

  • All-DAA regimens demonstrate high antiviral efficacy in HCV-infected CKD patients.
  • DAA therapies exhibit a favorable safety profile with minimal adverse drug reactions.
  • These regimens represent a significant advancement over older treatments.

Conclusions:

  • Direct-acting antiviral (DAA) combination therapies have transformed HCV management in CKD.
  • Next-generation DAAs offer a more effective and safer treatment option for this vulnerable population.

Keywords:
Direct-acting agentsKidney transplantationRenal insufficiency, chronicHepatitis C virus

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