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The effects of cigarette smoking and smoking cessation on high-density lipoprotein functions: implications for

Hong-Ying Chen1, Shi-Cheng Li1, Lian-Feng Chen1

  • 1Department of Cardiology, Peking Union Medical College Hospital (PUMCH), Beijing, P. R. China.

Annals of Clinical Biochemistry
|July 3, 2018
PubMed

Insights

Smoking cessation improves high-density lipoprotein (HDL) function in coronary artery disease patients, enhancing its antioxidant and anti-inflammatory properties. This highlights the importance of quitting smoking for cardiovascular health.

Area of Science:

  • Cardiovascular Disease Research
  • Lipid Metabolism and Function
  • Smoking Cessation Science

Background:

  • Smoking cessation improves coronary artery disease (CAD) prognosis.
  • Investigating the impact of smoking cessation on high-density lipoprotein (HDL) functionality in CAD patients.

Purpose of the Study:

  • To evaluate the effect of smoking cessation on HDL antioxidative and antichemotactic properties.
  • To assess HDL-induced cellular cholesterol efflux after smoking cessation in CAD patients.

Main Methods:

  • Prospective, randomized controlled study comparing CAD smokers, healthy smokers, and non-smokers.
  • Assessed HDL antioxidative and antichemotactic abilities, and cholesterol efflux before and after a 3-month cessation period.
  • In vitro experiments investigated effects of carbon monoxide and nicotine on HDL function.

Main Results:

  • HDL antioxidative and antichemotactic abilities were significantly reduced in CAD smokers compared to non-smokers.
  • Smoking cessation significantly improved HDL antioxidative and antichemotactic abilities in CAD patients.
  • HDL-induced cellular cholesterol efflux was not significantly increased by smoking cessation.

Conclusions:

  • Smoking cessation effectively enhances HDL function in CAD smokers.
  • This study reinforces the critical role of smoking cessation in the secondary prevention of CAD.
Abstract

Keywords:
Coronary artery diseaseantichemotaxisantioxidationcholesterol effluxhigh-density lipoproteinsmoking cessation

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