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Risk factors and angiographic profile of coronary slow flow (CSF) phenomenon in North Indian population: An

Saibal Mukhopadhyay1, Mitesh Kumar1, Jamal Yusuf1

  • 1Department of Cardiology, G. B. Pant Institute of Post Graduate Medical Education and Research (GIPMER), New Delhi, India.

Indian Heart Journal
|July 3, 2018
PubMed

Insights

Coronary slow flow (CSF) is linked to higher body mass index (BMI) in North India. This study found BMI to be the only independent risk factor for CSF in this population.

Area of Science:

  • Cardiology
  • Vascular Biology
  • Public Health

Background:

  • Coronary slow flow (CSF) is characterized by delayed opacification of coronary arteries without significant epicardial stenosis.
  • Previous research indicates variable risk factors for CSF across different ethnic groups.

Purpose of the Study:

  • To investigate the risk factors and angiographic profile of coronary slow flow (CSF) in the North Indian population.
  • To address the lack of prior studies on CSF in this demographic.

Main Methods:

  • A quantitative thrombolysis in myocardial infarction (TIMI) frame count method was used to assess CSF in 40 patients and 40 controls.
  • Evaluated clinical risk factors (age, sex, BMI, diabetes, hypertension, dyslipidemia, smoking) and biochemical markers (hematocrit, platelet count, uric acid, homocysteine, fibrinogen, hsCRP, HbA1c).

Main Results:

  • The study identified significantly higher BMI (p<0.001) and fibrinogen levels (p=0.04) in patients with CSF compared to controls.
  • Smoking was also more prevalent in the CSF group (60.0% vs 35.0%, p=0.02).
  • Multivariable regression analysis revealed body mass index (BMI) as the sole independent predictor of CSF (OR 1.613, p<0.001).

Conclusions:

  • This study provides the first analysis of CSF's clinical presentation, angiographic profile, and risk factors in the North Indian population.
  • Body mass index (BMI) emerged as the only independent risk factor associated with coronary slow flow in this cohort.
Abstract

Keywords:
Angiographic profileClinical presentationCoronary slow flowNorth Indian populationRisk factors

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