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Clinical Application of High-pitched Breath Sound in Children with Asthma

Yoshimi Kondo, Mariko Nukaga, Mayumi Enseki

  • 1Department of Pediatrics, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan. mochihi@tokai-u.jp.

The Tokai Journal of Experimental and Clinical Medicine
|July 3, 2018
PubMed

Insights

New breath sound parameters, A1000 and A1000/AT, effectively assess airway conditions and bronchial reversibility in children with asthma. These biomarkers correlate with spirometry, offering a novel approach to asthma evaluation.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Medicine
  • Biomarkers in Asthma

Background:

  • Breath sound analysis is emerging as a potential biomarker for airway conditions in asthma.
  • Evaluating asthmatic children requires sensitive and specific methods for assessing airway status.

Purpose of the Study:

  • To investigate novel breath sound parameters for their utility in evaluating asthmatic children.
  • To determine if new breath sound parameters can serve as biomarkers for airway conditions.

Main Methods:

  • Fifty-seven children (ages 6-16) were studied.
  • New parameters, Area Under the Curve > 1,000 Hz (A1000) and A1000/Total AUC (A1000/AT), were measured before and after beta2-agonist inhalation.
  • Spirography and forced oscillation technique were also employed.

Main Results:

  • A1000 showed a negative correlation with FEV1 (p=0.028).
  • Increases in FEV1 (ΔFEV1) correlated with decreases in A1000 (ΔA1000, p=0.001) and ΔA1000/AT (p=0.036).

Conclusions:

  • A1000 reflects airway condition in asthmatic children.
  • ΔA1000 and ΔA1000/AT effectively describe airway dilatation.
  • These novel breath sound parameters are valuable for assessing bronchial reversibility in pediatric asthma.
Abstract

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