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Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform
Published on: August 17, 2022
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Preimplantation genetic testing in assisted reproductive technology.
Valeria Romanelli1, Maurizio Poli1,2, Antonio Capalbo3,4
1Igenomix, Marostica, Vicenza, Italy.
Panminerva Medica
|July 3, 2018
Summary
Preimplantation genetic testing (PGT) analyzes embryo genetics for assisted reproduction. Technologies have advanced significantly, offering more precise and comprehensive diagnostic strategies for clinical use.
Area of Science:
- Reproductive Medicine
- Genetics
- Embryology
Background:
- Preimplantation genetic testing (PGT) is a key diagnostic tool in assisted reproduction.
- It has been utilized for nearly thirty years to assess embryo genetic composition.
- Continuous technological advancements have enhanced PGT's precision and scope.
Purpose of the Study:
- To review the primary diagnostic approaches for embryo genetic and chromosomal assessment.
- To discuss these methods from both embryological and genetic perspectives.
Main Methods:
- Review of current preimplantation genetic testing methodologies.
- Analysis of technological evolution in embryo genetic analysis.
- Discussion of clinical applications and advancements.
Main Results:
- Description of various PGT diagnostic strategies.
- Evaluation of improvements in precision, comprehensiveness, and robustness of PGT.
- Highlighting of current clinical practices in embryo genetic assessment.
Conclusions:
- PGT technologies have evolved substantially over three decades.
- Modern PGT offers robust and precise genetic and chromosomal assessments.
- The review provides a comprehensive overview of PGT from multiple scientific viewpoints.
