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Related Concept Videos

Next-generation Sequencing03:00

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The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
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Decreasing Function01:27

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A decreasing function describes a relationship where the output consistently declines as the input increases. This means that for any two input values, if one is greater than the other, the corresponding output is smaller. Mathematically, a function f is decreasing on an interval I if for every x1 < x2​ in I, f (x1) > f (x2). This type of behavior is visually identified on a graph that slopes downward from left to right.The nature of a function can be analyzed by calculating...
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A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
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Bradycardia is a medical condition in which the heart rate is slower than normal. It occurs when the heart's natural pacemaker, the sinus node, generates slower electrical impulses than the standard rhythm. In adults, bradycardia is diagnosed when the pulse rate falls below 60 beats per minute, indicating a deviation from the normal heart rate range.
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Per-Unit Sequence Models01:26

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An ideal Y-Y transformer, grounded through neutral impedances, displays per-unit sequence networks akin to those of a single-phase ideal transformer when subjected to balanced positive- or negative-sequence currents. These currents do not produce neutral currents, and their associated voltage drops.
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Frequency-dependent Selection01:21

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When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
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Related Experiment Video

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Protocol for Human Blastoids Modeling Blastocyst Development and Implantation
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Estimation of age-dependent decrease in blastocyst euploidy by next generation sequencing: development of a novel

Sandro C Esteves1,2, José F Carvalho3, Ciro D Martinhago4

  • 1Andrology and Human Reproduction Clinic, ANDROFERT, Campinas, Brazil - s.esteves@androfert.com.br.

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Female age significantly impacts blastocyst euploidy rates, decreasing with each year. This study provides a model to predict euploid embryo likelihood and determine the number of blastocysts needed for successful IVF/ICSI treatment.

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Area of Science:

  • Reproductive Medicine
  • Genetics
  • Biostatistics

Background:

  • Female age is a critical factor influencing blastocyst euploidy.
  • Blastocyst cohort size affects the probability of obtaining a euploid embryo for transfer.

Purpose of the Study:

  • To develop a predictive model for age-dependent blastocyst euploidy.
  • To assess the impact of blastocyst cohort size on achieving at least one euploid embryo.

Main Methods:

  • Retrospective analysis of 1296 trophectoderm biopsies using next-generation sequencing.
  • Logistic regression model incorporating female age (quadratic fit) and embryo genetic status.
  • Model validation through cross-validation and data splitting techniques.

Main Results:

  • Blastocyst euploidy probability decreases with female age, following an age-dependent binomial distribution (1.2%–24.5% for ages 28–44).
  • Calculated minimum blastocyst numbers needed for a 90% chance of at least one euploid embryo increase with age (e.g., 3 at age 28, 29 at age 45).

Conclusions:

  • A novel model accurately estimates blastocyst euploidy probability based on female age.
  • The model aids clinicians in counseling and treatment planning for infertile couples undergoing IVF/ICSI by considering female age and blastocyst cohort size.