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Published on: January 12, 2018
Voice Abnormalities and Laryngeal Pathology in Preterm Children
Anne Hseu1, Nohamin Ayele1, Kosuke Kawai1
11 Boston Children's Hospital, Department of Otolaryngology and Communication Enhancement, Boston, Massachusetts, USA.
Insights
Premature infants with prolonged intubation or NICU stays often experience severe voice problems. Early clinical evaluation for dysphonia is recommended for these children.
Area of Science:
- Pediatric Otolaryngology
- Speech and Language Pathology
- Neonatology
Background:
- Voice abnormalities affect up to 58% of children born prematurely.
- Limited research exists on laryngeal pathologies and laryngoscopic findings in this population.
Purpose of the Study:
- To review voice abnormalities in premature patients.
- To characterize the causes of voice problems and correlate findings with intubation and surgical history.
Main Methods:
- Retrospective chart review of preterm patients in a pediatric voice clinic.
- Analysis of demographic data, diagnoses, laryngoscopies, and treatment history.
Main Results:
- Fifty-seven preterm patients were analyzed (mean gestational age 27.8 weeks).
- Prolonged intubation (≥28 days) or NICU stay (>12 weeks) correlated with higher dysphonia severity.
- Vocal fold hypo/immobility was associated with greater voice deviance; 35% recommended surgery, 49% voice therapy.
Conclusions:
- Prolonged intubation and NICU stays are linked to increased dysphonia severity in premature infants.
- A low threshold for clinical evaluation of dysphonia is warranted in this high-risk group.
Introduction:
The prevalence of voice abnormalities in children born prematurely has been reported to be as high as 58%. Few studies have examined these abnormalities with laryngoscopic or videostroboscopic findings and characterized their laryngeal pathologies.
Objective:
To review voice abnormalities in patients with a history of prematurity and characterize the etiology of their voice problems. A secondary objective is to see if there is a correlation between the findings and the patient's intubation and surgical history.
Methods:
A retrospective chart review was conducted of all preterm patients seen in voice clinic at a tertiary pediatric hospital. Demographic data, diagnoses, and office laryngoscopies were reviewed as well as any speech therapy evaluations and/or medical and surgical treatments.
Results:
Fifty-seven patients were included. Mean age at presentation was 5.1 (±4.3) years. Mean gestational age was 27.8 (±3.7) weeks. Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V) perceptual evaluations included a mean overall dysphonia severity of 46.6 (±24.2). Patients who had undergone prolonged intubation (⩾28 days) in the NICU or had prolonged NICU stays (>12 weeks) had significantly higher overall dysphonia severity scores. Thirty-three patients with vocal fold hypo- or immobility had significantly greater voice deviance in breathiness, loudness, and overall severity compared to those without vocal fold immobility. Of all patients, 35% were recommended surgical intervention and 49% voice therapy.
Conclusion:
Intubation greater than 28 days and prolonged NICU stays are associated with more severe dysphonia in premature patients. There should be a low threshold for clinical evaluation of dysphonia in this unique patient population.
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