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Does hypothyroidism augment sun-induced skin damage?
Georgeta Bocheva1, Maria Valcheva-Traykova2, Boycho Landzhov3
1a Department of Pharmacology and Toxicology, Faculty of Medicine , Sofia Medical University , Sofia , Bulgaria.
Summary
Hypothyroidism exacerbates skin damage from prolonged UV exposure by increasing oxidative stress and lipid peroxidation. This highlights hypothyroidism as a risk factor for photoaging and photocarcinogenesis.
Area of Science:
- Dermatology
- Endocrinology
- Biochemistry
Background:
- Overt hypothyroidism and chronic sunlight exposure can impact skin health.
- Oxidative stress plays a role in skin damage, aging, and cancer development.
Purpose of the Study:
- To investigate the combined effects of hypothyroidism and prolonged UV exposure on skin.
- To assess free radical accumulation and oxidative damage in the skin under these conditions.
Main Methods:
- Measured free radical accumulation using MTT assay.
- Assessed pro-oxidant enzymes: xanthine oxidase (XO) and NADPH-diaphorase.
- Quantified cellular damage via malondialdehyde (MDA) as a marker of lipid peroxidation.
Main Results:
- UV exposure increased XO and NADPH-diaphorase activity in both euthyroid and hypothyroid skin as a protective response.
- These protective enzyme activities were reduced in hypothyroid rats.
- Hypothyroid skin exhibited greater lipid peroxidation following UV exposure compared to euthyroid skin.
Conclusions:
- Hypothyroidism is a risk factor for increased oxidative skin damage in chronically photo-exposed skin.
- Lipid peroxidation is a key pathway through which photo-oxidative stress contributes to photocarcinogenesis and photo-aging.
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