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Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
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Lung Transplantation with Controlled Donation after Circulatory Death Donors

Ilhan Inci1, Sven Hillinger1, Didier Schneiter1

  • 1Department of Thoracic Surgery, Zurich University Hospital, Switzerland.

Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
|July 3, 2018
PubMed

Insights

Lung transplants using donation after circulatory death (DCD) donors show comparable long-term survival rates to those from donation after brain death (DBD) donors, offering a safe solution to donor shortages.

Area of Science:

  • Thoracic surgery
  • Transplantation immunology
  • Organ donation

Background:

  • Donor shortage is a critical issue in lung transplantation.
  • Donation after circulatory death (DCD) offers a potential solution to increase organ availability.

Purpose of the Study:

  • To evaluate the long-term outcomes of lung transplantation (LTx) using DCD donors.
  • To compare the survival rates of LTx recipients from DCD versus donation after brain death (DBD) donors.

Main Methods:

  • Retrospective analysis of consecutive DCD (Maastricht Category III) and DBD donor lung transplants.
  • Comparison of survival rates between DCD and DBD groups as the primary outcome measure.

Main Results:

  • No 90-day mortality observed in the DCD group.
  • 1- and 3-year survival rates were 100% and 80% for DCD donors versus 85% and 69% for DBD donors (p=0.4).
  • Primary graft dysfunction (PGD) grade 3 occurred in three recipients; chronic lung allograft dysfunction (CLAD) caused death in two cases.

Conclusions:

  • Lung transplantation from DCD donors demonstrates comparable long-term outcomes to those from DBD donors.
  • The utilization of DCD donors is a safe and effective strategy to address the shortage of donor lungs.
Abstract

Keywords:
controlled DCDdonation after cardiac deathlung transplantationsurvival

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