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Updated: Feb 8, 2026
08:03
Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
Published on: December 1, 2016
9.5K
[Development of an Anticancer Therapy Using Recombinant Bifidobacterium as a New Drug Delivery System (DDS)]
Yuichiro Taira1, Ikuko Taira1, Takeshi Nisikawa1
1Department of Pharmaceutical Sciences, Teikyo Heisei University.
Summary
Obligate anaerobic bacteria, like Bifidobacterium longum, specifically target tumors due to unique tumor microenvironments. This research explores their use in novel cancer drug delivery systems, offering a safer alternative to traditional methods.
Area of Science:
- Microbiology
- Oncology
- Biotechnology
Background:
- Obligate anaerobic bacteria, including bifidobacteria, exhibit tumor-specific growth.
- Tumor vasculature contains microcracks facilitating bacterial entry.
- Hypoxic tumor microenvironments support anaerobic bacterial survival and proliferation.
Purpose of the Study:
- To investigate the potential of Bifidobacterium longum as a targeted drug delivery vehicle for cancer therapy.
- To develop a novel drug delivery system utilizing Bifidobacterium longum for specific anti-tumor antibody release.
Main Methods:
- Intravenous administration of Bifidobacterium longum.
- Utilizing Bifidobacterium longum's tumor-homing properties for drug delivery.
- Developing antibody-drug conjugates or single-chain antibodies for targeted release.
Main Results:
- Bifidobacterium longum specifically colonizes tumor tissues.
- Gram-positive bifidobacteria do not produce endotoxins, mitigating risks of endotoxin shock.
- Demonstrated potential for targeted delivery of anti-tumor antibodies to tumor sites.
Conclusions:
- Bifidobacterium longum offers a promising platform for targeted cancer drug delivery.
- The system leverages bacterial tropism and the tumor microenvironment for enhanced efficacy and safety.
- This approach presents a novel strategy for developing advanced anti-cancer therapeutics.
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