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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Related Experiment Video

Updated: Feb 8, 2026

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors
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Interplay between inflammatory tumor microenvironment and cancer stem cells.

Shijian Zhang1,2, Xi Yang1,2, Lei Wang1,2

  • 1Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China.

Oncology Letters
|July 3, 2018
PubMed
Summary

Cancer stem cells (CSCs) interact with the tumor microenvironment, driving cancer initiation and spread. This review highlights how inflammation, including cytokines and immune cells, influences CSCs, offering insights for improved cancer treatments.

Keywords:
cancer stem cellsinflammatory factorsinterferonsmyeloid-derived suppressor cellstumor microenvironmenttumor necrosis factortumor-associated macrophages

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Area of Science:

  • Oncology and Cancer Biology
  • Tumor Microenvironment Research
  • Cancer Stem Cell Biology

Background:

  • Cancer stem cells (CSCs) are crucial for tumor initiation, progression, and metastasis.
  • The tumor microenvironment, particularly inflammation, significantly impacts cancer development.
  • Existing research links inflammatory processes to tumor growth and spread.

Purpose of the Study:

  • To review the intricate relationship between cancer stem cells and inflammatory components.
  • To elucidate the role of inflammatory cytokines and cells in cancer progression.
  • To identify key factors for improving clinical outcomes in cancer treatment.

Main Methods:

  • Literature review synthesizing current research on CSCs and inflammation.
  • Analysis of studies focusing on inflammatory cytokines (e.g., IFNs, TNF, IL-6, IL-17).
  • Examination of the role of inflammatory cells (e.g., MDSCs, TAMs) in cancer.

Main Results:

  • CSCs are closely associated with the tumor microenvironment.
  • Inflammatory components, including specific cytokines and immune cells, are integral to tumor initiation and progression.
  • Understanding these interactions is vital for therapeutic strategies.

Conclusions:

  • The interplay between CSCs and the inflammatory tumor microenvironment is a critical determinant of cancer progression.
  • Targeting inflammatory pathways and their interaction with CSCs holds promise for novel cancer therapies.
  • Further research into these key factors can lead to improved clinical outcomes for various cancer types.