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Updated: Feb 8, 2026
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Mouse- and Human-derived Primary Gastric Epithelial Monolayer Culture for the Study of Regeneration
Published on: May 7, 2018
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Primary Gastric Lymphoma: Clinicopathological Profile
Renuka Malipatel1, Mallikarjun Patil2, Patil Pritilata Rout1
1Department of Pathology, St. John's Medical College, Bengaluru, Karnataka, India.
Euroasian Journal of Hepato-Gastroenterology
|July 3, 2018
Summary
Primary gastric lymphoma (PGL) often presents with vague symptoms like abdominal pain. Diffuse large B-cell lymphoma (DLBCL) is the most common subtype, highlighting the need for early biopsy in suspected cases.
Area of Science:
- Gastroenterology
- Oncology
- Hematology
Background:
- The gastrointestinal tract is the most common extranodal site for non-Hodgkin's lymphoma (NHL).
- Primary gastric lymphoma (PGL) originates from mucosa-associated lymphoid tissue (MALT), often linked to *Helicobacter pylori* infection.
- PGL typically presents with nonspecific gastrointestinal symptoms.
Purpose of the Study:
- To investigate the clinicopathological characteristics of primary gastric lymphoma (PGL).
- To analyze the common histological subtypes and patient demographics of PGL.
- To correlate clinical presentation with histopathological findings in PGL.
Main Methods:
- Retrospective analysis of 43 PGL cases from 2006 to 2016.
- Review of histopathology slides and immunohistochemistry (IHC) markers.
- Correlation of immunoprofile for lymphoma subtyping.
Main Results:
- Diffuse large B-cell lymphoma (DLBCL) was the predominant histological subtype.
- Common presenting symptoms included abdominal pain and new-onset dyspepsia.
- *Helicobacter pylori* infection was present in 41% of patients; most cases were Stage II or III.
Conclusions:
- Nonspecific symptoms like abdominal pain and dyspepsia warrant high clinical suspicion for PGL.
- Early detection through biopsy of suspicious gastric lesions is crucial.
- DLBCL is the most frequent histological subtype of PGL in this South Indian cohort.
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