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Related Experiment Video

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Remote Laboratory Management: Respiratory Virus Diagnostics
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[Research Progress in Laboratory Diagnostic Methods for HEV Infection].

Wenfang Ji, Guiping Wen, Zimin Tang

    Bing Du Xue Bao = Chinese Journal of Virology
    |July 3, 2018
    PubMed
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    Hepatitis E virus (HEV) screening for blood donors is crucial. Current methods like HEV RNA testing are effective, but antigen tests may offer complementary benefits for ensuring blood transfusion safety.

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    Area of Science:

    • Hepatology and Virology
    • Transfusion Medicine and Public Health

    Background:

    • Hepatitis E virus (HEV) causes a significant global public health concern, primarily transmitted via the fecal-oral route.
    • Blood-borne transmission of HEV poses a risk to transfusion safety, necessitating robust screening protocols for blood donors.
    • Existing diagnostic methods for HEV include HEV RNA, HEV antigen, anti-HEV IgM, and anti-HEV IgG.

    Purpose of the Study:

    • To analyze current HEV diagnostic methods for their application in blood donor screening.
    • To provide references for effective HEV screening strategies to enhance blood transfusion safety.
    • To evaluate the significance of various HEV detection markers for infection control.

    Main Methods:

    • Review and analysis of existing diagnostic methods for Hepatitis E virus detection.
    • Evaluation of HEV RNA, HEV antigen, anti-HEV IgM, and anti-HEV IgG as screening markers.
    • Assessment of the suitability of these markers for detecting HEV in blood donors.

    Main Results:

    • HEV RNA testing is the 'gold standard' for HEV infection detection, particularly useful in chronic, immunosuppressed, or non-hepatic cases.
    • HEV antigen testing serves as an indicator of current HEV infection and is suitable for blood donor screening and acute infection diagnosis.
    • Anti-HEV IgM indicates recent infection, while anti-HEV IgG signifies past infection, neither being sole indicators for acute HEV diagnosis.

    Conclusions:

    • Current blood donor screening for HEV predominantly relies on nucleic acid testing (HEV RNA).
    • HEV antigen testing presents a potential complementary method to address limitations in current screening protocols.
    • Further research is required to validate the efficacy of antigen and antibody tests for blood donor screening.