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Related Experiment Video

Updated: Feb 8, 2026

Large Area Substrate-Based Nanofabrication of Controllable and Customizable Gold Nanoparticles Via Capped Dewetting
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Gold Nanoparticles Bearing a Tumor pH-Sensitive Cyclodextrin Cap.

Mijin Koo1, Kyung Taek Oh2, Gwangjin Noh1

  • 1Department of Biotechnology , The Catholic University of Korea , 43 Jibong-ro , Bucheon-si , Gyeonggi-do 14662 , Republic of Korea.

ACS Applied Materials & Interfaces
|July 3, 2018
PubMed
Summary

Functional gold nanoparticles (AuNPs) with a pH-sensitive cyclodextrin (CD) cap show enhanced tumor uptake. This pH-triggered release system improves light-driven therapy for solid tumors.

Keywords:
gold nanoparticlespH-sensitive cyclodextrin capphotodynamic therapyphotothermal therapytumor acidic pH

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Area of Science:

  • Nanomedicine
  • Biotechnology
  • Materials Science

Background:

  • Gold nanoparticles (AuNPs) are investigated for targeted cancer therapy.
  • Developing stimuli-responsive drug delivery systems is crucial for enhancing therapeutic efficacy.
  • Tumor microenvironments, often acidic, present opportunities for targeted drug release.

Purpose of the Study:

  • To develop pH-sensitive functional gold nanoparticles (AuNPs) for targeted tumor therapy.
  • To investigate the controlled release of therapeutic agents triggered by tumor acidity.
  • To evaluate the efficacy of AuNP-mediated photothermal and photodynamic therapy in acidic solid tumors.

Main Methods:

  • Functionalization of AuNPs with pH-sensitive cyclodextrin (CD) caps.
  • Surface modification with dopamine and amine groups (dCD-NH2) and dimethylmaleic acid and chlorin e6 (cCD-DMA).
  • Assessment of nanoparticle complex stability and drug release in acidic conditions (pH 6.8).
  • Evaluation of cellular uptake and light-driven (photothermal and photodynamic) ablation of tumor cells.

Main Results:

  • The ionic complex of dCD-NH2 and cCD-DMA on AuNPs destabilized in acidic tumor environments, releasing cCD.
  • AuNPs with dCD-NH2 exhibited enhanced electrostatic attraction to tumor cells, increasing cellular uptake.
  • Significant increase in light-driven photothermal and photodynamic ablation of acidic solid tumors was observed.

Conclusions:

  • pH-sensitive AuNPs with CD caps offer a promising strategy for targeted tumor therapy.
  • The triggered release mechanism enhances AuNP accumulation and therapeutic effectiveness in acidic tumors.
  • This approach holds significant potential for improving outcomes in solid tumor treatment.