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[EPIGENETIC MECHANISMS IN MODELS OF CHRONIC PAIN - A TARGET FOR NOVEL THERAPY?]

Saar Anis1,2, Amnon Mosek1,2,3

  • 1Neurology Department, Sourasky Medical Center, Tel Aviv, Israel.

Harefuah
|July 3, 2018
PubMed
Abstract

Insights

Epigenetic modifications in the sensory circuit influence chronic pain development. Targeting these epigenetic processes offers potential therapeutic strategies for pain management.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Epigenetics plays a crucial role in the physiological response to injury.
  • Epigenetic alterations in the sensory circuit are critical for pain perception.
  • Dysregulation of epigenetic processes is implicated in chronic pain development.

Purpose of the Study:

  • To review the role of epigenomic modifications in chronic pain.
  • To summarize the therapeutic potential of targeting epigenetic processes for pain relief.

Main Methods:

  • Literature review of epigenetics and chronic pain research.
  • Analysis of epigenetic mechanisms in pain pathways.
  • Evaluation of current and emerging therapeutic strategies.

Main Results:

  • Epigenetic changes, including DNA methylation and histone modifications, are key drivers of chronic pain.
  • These alterations affect gene expression within the sensory nervous system.
  • Therapeutic interventions targeting epigenetic enzymes show promise.

Conclusions:

  • Epigenetic modifications are fundamental to the pathophysiology of chronic pain.
  • Modulating epigenetic processes represents a promising avenue for novel pain therapies.

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