[Hoffmann syndrome : about two new cases]

Area of Science:

• Endocrinology
• Neurology
• Muscle Physiology

Background:

• Hypothyroidism, a common endocrine disorder, typically presents with metabolic and systemic symptoms.
• Hypertrophic myopathy, characterized by muscle enlargement, is an uncommon manifestation of endocrine dysfunction.
• Hoffmann syndrome is a rare condition linking hypothyroidism to muscle hypertrophy.

Observation:

• Two adult male patients, aged 49 and 57, presented with severe hypothyroidism.
• Both patients exhibited clinical and pathological features consistent with hypertrophic myopathy, a rare sign of Hoffmann syndrome.

Findings:

• The cases highlight that severe hypothyroidism can exceptionally manifest as hypertrophic myopathy (Hoffmann syndrome).
• This underscores the importance of considering endocrine evaluation in patients with unexplained myopathies.

Implications:

• Early recognition of Hoffmann syndrome as a potential sign of hypothyroidism can lead to timely diagnosis and treatment.
• This case series expands the understanding of the diverse clinical presentations of hypothyroidism.
• Prompt management of hypothyroidism can prevent or reverse neurological and muscular complications.