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[Hoffmann syndrome : about two new cases].

F Saïd1,2, A Tliba1,2, M Khanfir1,2

  • 1Service de Médecine interne, Hôpital La Rabta.

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|July 3, 2018
PubMed
Summary
This summary is machine-generated.

Severe hypothyroidism can exceptionally manifest as Hoffmann syndrome, a rare hypertrophic myopathy. This report details two new cases in middle-aged men, highlighting this unusual presentation.

Keywords:
Hoffmann syndromeHypothyroidismMyopathyMyxedema

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Area of Science:

  • Endocrinology
  • Neurology
  • Muscle Physiology

Background:

  • Hypothyroidism, a common endocrine disorder, typically presents with metabolic and systemic symptoms.
  • Hypertrophic myopathy, characterized by muscle enlargement, is an uncommon manifestation of endocrine dysfunction.
  • Hoffmann syndrome is a rare condition linking hypothyroidism to muscle hypertrophy.

Observation:

  • Two adult male patients, aged 49 and 57, presented with severe hypothyroidism.
  • Both patients exhibited clinical and pathological features consistent with hypertrophic myopathy, a rare sign of Hoffmann syndrome.

Findings:

  • The cases highlight that severe hypothyroidism can exceptionally manifest as hypertrophic myopathy (Hoffmann syndrome).
  • This underscores the importance of considering endocrine evaluation in patients with unexplained myopathies.

Implications:

  • Early recognition of Hoffmann syndrome as a potential sign of hypothyroidism can lead to timely diagnosis and treatment.
  • This case series expands the understanding of the diverse clinical presentations of hypothyroidism.
  • Prompt management of hypothyroidism can prevent or reverse neurological and muscular complications.