Related Experiment Video
Updated: Feb 8, 2026
03:53
Author Spotlight: Exploring Behavioral Pathways Through Cross-Species Insights in Foraging and Communication
Published on: November 17, 2023
1.6K
Rivaroxaban: searching the integral vascular protection
Vivencio Barrios1, Manuel Almendro-Delia2, Lorenzo Facila3
1a Cardiology Department , Hospital Ramón y Cajal , Madrid , Spain.
Expert Review of Clinical Pharmacology
|July 3, 2018
Summary
Rivaroxaban offers vascular protection beyond anticoagulation in patients with cardiovascular disease or atrial fibrillation. Studies show it reduces cardiovascular events, suggesting a broader protective role.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Residual cardiovascular risk persists in patients with atherosclerotic cardiovascular disease (ASCVD) despite current antithrombotic therapies.
- Atrial fibrillation (AF) patients face elevated risks of myocardial infarction and cardiovascular death.
- Novel antithrombotic strategies are needed to mitigate these risks.
Purpose of the Study:
- To review the vascular protective role of rivaroxaban in patients with cardiovascular disease and/or atrial fibrillation.
- To analyze clinical trial data on rivaroxaban's effects beyond its anticoagulant activity.
Main Methods:
- Review of clinical trials, including COMPASS and ROCKET-AF.
- Analysis of experimental data on rivaroxaban's anti-inflammatory, antioxidative, and endothelial function effects.
Main Results:
- In stable ASCVD patients, rivaroxaban (2.5 mg BID) plus aspirin showed superior cardiovascular protection compared to aspirin alone (COMPASS trial).
- In nonvalvular AF patients, rivaroxaban (20 mg QD) was non-inferior to warfarin for stroke prevention, with a trend towards reduced cardiovascular outcomes (ROCKET-AF trial).
- Experimental data suggest rivaroxaban possesses anti-inflammatory and antioxidative properties, potentially improving endothelial dysfunction.
Conclusions:
- Rivaroxaban demonstrates vascular protective effects that extend beyond its anticoagulant properties.
- The findings support rivaroxaban's potential role in managing patients with ASCVD and/or AF.
- Further research may elucidate the full spectrum of rivaroxaban's vascular benefits.
Related Concept Videos
03:24Seedless Vascular Plants
67.1K
Seedless Vascular Plants Were the First Tall Plants on Earth
67.1K
02:31Protection of Alcohols
8.1K
This lesson delves into the concept of protection and deprotection of a functional group fundamental to synthetic organic chemistry. These phenomena are explained in the context of aliphatic and aromatic alcohols.
Protection
It defines a protecting group as the masking agent to make the more reactive species inert to a given set of conditions. This concept is depicted via the illustration of liquid flow through different outlets in an assembly of pipes. The analogy helps to understand the role...
Protection
It defines a protecting group as the masking agent to make the more reactive species inert to a given set of conditions. This concept is depicted via the illustration of liquid flow through different outlets in an assembly of pipes. The analogy helps to understand the role...
8.1K
01:16Zones of Protection
808
In power systems, the entire setup is divided into protective zones to isolate faults and protect the rest of the network. These zones include generators, transformers, buses, transmission lines, distribution lines, and motors. Each zone can be visualized as a separate room in a house, with each room protected by its own circuit breaker.
Protective zones are defined by closed dashed lines, containing one or more components. A key characteristic of these zones is the strategic placement of...
Protective zones are defined by closed dashed lines, containing one or more components. A key characteristic of these zones is the strategic placement of...
808
01:23Radial System Protection
447
Radial systems employ time-delay overcurrent relays to reduce load interruptions. When a fault occurs, the nearest breaker opens first, while upstream breakers remain closed due to longer delay settings. This approach ensures minimal disruption to the rest of the system.
In a radial system with a fault downstream of the third breaker, ideally, only the third breaker will open, isolating the fault and interrupting the load connected beyond it. The second breaker has a longer delay setting,...
In a radial system with a fault downstream of the third breaker, ideally, only the third breaker will open, isolating the fault and interrupting the load connected beyond it. The second breaker has a longer delay setting,...
447
01:27Protecting Self-Esteem
224
Self-esteem, a central component of psychological well-being, is actively maintained through various cognitive and behavioral strategies. Individuals employ specific mechanisms to preserve a positive self-concept and mitigate threats to their self-worth, particularly in contexts involving social evaluation or personal feedback. Four primary techniques are commonly used to sustain self-esteem.Manipulating AppraisalsOne prominent strategy involves manipulating appraisals from others. Individuals...
224
01:26Integration by Parts: Indefinite Integrals
206
Integration by parts is a fundamental technique in calculus for evaluating integrals involving the product of two functions. It is particularly useful when direct integration is not feasible. The method is based on the product rule for differentiation, which states that the derivative of a product equals the derivative of the first function times the second, plus the first function times the derivative of the second. By integrating this identity and rearranging terms, the integration by parts...
206