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An Age-Based Analysis of Pediatric Melanoma: Staging, Surgery, and Mortality in the Surveillance, Epidemiology, and
Patrick H Lam1, Augustine C Obirieze, Gezzer Ortega
1Howard University College of Medicine, Washington, District of Columbia, USA.
Insights
Pediatric melanoma management lacks clear guidelines. Younger children (≤12 years) present with later-stage melanomas, receive less invasive surgery, and have poorer survival rates, indicating significant disparities.
Area of Science:
- Oncology
- Pediatric Medicine
- Epidemiology
Background:
- Pediatric melanoma is not well-characterized.
- Management guidelines for pediatric melanoma are undefined.
- Understanding population characteristics and outcomes is crucial for improving care.
Purpose of the Study:
- To identify the pediatric melanoma population.
- To analyze treatment modalities and outcomes.
- To investigate age-related disparities in melanoma management.
Main Methods:
- Utilized the Surveillance, Epidemiology, and End Results (SEER) database (2004-2008).
- Included patients aged 21 years or younger diagnosed with melanoma.
- Grouped patients into three age categories: ≤12 years, 13-18 years, and 19-21 years.
Main Results:
- 1255 pediatric melanoma cases were analyzed.
- Younger patients (≤12 years) had higher proportions of Stage IV melanoma (3.6%) compared to older groups (0.9%).
- Patients aged 19-21 years showed worse survival rates (HR: 5.26) than the ≤12 years group.
Conclusions:
- Significant disparities exist in pediatric melanoma care.
- Younger children (≤12 years) experience later-stage diagnosis, less aggressive surgical treatment, and reduced survival.
- Further research is needed to identify prognostic factors for better management of pediatric melanoma.
Abstract:
The pediatric melanoma population is not well described, and current guidelines for their management are not well defined. Our study aims to identify this population, treatment modalities, and outcomes using a national population-based database. We reviewed the Surveillance, Epidemiology, and End Results database (2004-2008). Patients ≤21 years old with melanoma were included and grouped into ≤12 years of age, 13 to 18 years, and 19 to 21 years. Clinical characteristics were analyzed across the groups. A total of 1255 patients were included: 52.7 per cent were 19 to 21 years of age, 36.3 per cent were 13 to 18 years of age, and 11.0 per cent were ≤12 years of age. The 19- to 21-year-olds had the highest proportion of stage I (50.5%) versus ≤12 years of age (31.9%); the ≤12-year-olds had the highest proportion of stage IV (3.6%) versus 19 to 21 years of age (0.9%), P < 0.001. The 19- to 21-year-olds had the highest proportion receiving wide local excisions only (34.8%) versus ≤12 years of age (26.4%); the ≤12-year-olds had the highest proportion of patients without any surgeries (16.0%) versus 13 to 18 years of age (9.4%), P = 0.169. On adjusted analysis, the 19- to 21-year-olds had worse survival compared with ≤12 years of age (hazard ratio: 5.26, P = 0.017, 95% confidence interval 1.34-20.65). Disparities were found in the ≤12-year-old melanoma population, as they had later stage melanomas, less invasive surgery, and lower survival. Clearer prognostic factors are needed to better elucidate their management.
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