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Radiologically isolated syndrome in children: Current knowledge and future directions
1Division of Neurology, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Multiple Sclerosis and Related Disorders
|July 4, 2018
Summary
Radiologically isolated syndrome (RIS) involves white matter abnormalities on MRI without symptoms. This review focuses on RIS in children, its link to multiple sclerosis (MS), and management strategies.
Area of Science:
- Neurology
- Radiology
- Pediatrics
Background:
- Incidental brain MRI findings are common.
- White matter abnormalities without symptoms are termed radiologically isolated syndrome (RIS).
- RIS resembles demyelinating lesions seen in multiple sclerosis (MS).
Purpose of the Study:
- To review radiologically isolated syndrome (RIS) in children.
- To explore the significance of RIS in pediatric populations.
- To discuss current definitions, association with MS, and therapeutic interventions for pediatric RIS.
Main Methods:
- Literature review of observational studies on RIS.
- Focus on studies involving adult and pediatric populations.
- Analysis of subsequent clinical events and MS diagnosis risk.
Main Results:
- Growing interest in RIS and its progression to MS.
- Adult studies show a high rate of subsequent clinical events.
- Pediatric MS exhibits higher disease activity and burden.
Conclusions:
- Understanding RIS in children is crucial due to higher disease burden.
- Review provides an overview of pediatric RIS, its MS association, and treatments.
- Suggestions for assessment, surveillance, and future research in pediatric RIS are proposed.
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