Related Experiment Video
Updated: Feb 8, 2026
09:32
Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
Published on: February 8, 2018
15.5K
Author Correction: High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy
Carsten Krieg1,2, Malgorzata Nowicka3,4, Silvia Guglietta5
1Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland. kriegc@musc.edu.
Nature Medicine
|July 4, 2018
Summary
This study corrects errors in figures analyzing anti-PD-1 therapy responses. Healthy donor samples were re-analyzed to ensure accurate data representation in immune checkpoint inhibitor research.
Area of Science:
- Immunology
- Oncology
Context:
- Accurate data analysis is crucial for understanding anti-PD-1 therapy efficacy.
- Previous analyses contained errors due to sample misallocation.
Purpose:
- To correct and re-analyze data concerning anti-PD-1 therapy in healthy donors.
- To ensure the integrity of findings related to immune checkpoint inhibitor treatment.
Summary:
- Corrected figures reflect accurate analysis of healthy donor (HD) samples.
- Re-analysis involved correcting the use of HD2 and incorporating HD3 samples at baseline and 12 weeks.
- Ensured proper sample allocation for robust assessment of anti-PD-1 therapy effects.
Impact:
- Provides corrected data for reliable interpretation of anti-PD-1 therapy effects.
- Enhances the accuracy of research on immune checkpoint inhibitors.
- Supports future studies in immuno-oncology by ensuring data fidelity.
Related Concept Videos
02:20Milgram's Obedience to Authority
7.4K
Obedience to authority is classically demonstrated in a more famous series of social psychology experiments performed by Stanley Milgram. He was a social psychology professor at Yale who was influenced by the trial of Adolf Eichmann, a Nazi war criminal. Eichmann’s defense for the atrocities he committed was that he was “just following orders.”
7.4K
03:40Dimensional Analysis
65.0K
Dimensional analysis, also known as the factor label method, is a versatile approach for mathematical operations. The main principle behind this approach is: the units of quantities must be subjected to the same mathematical operations as their associated numbers. This method can be applied to computations ranging from simple unit conversions to more complex and multi-step calculations involving several different quantities and their units.
Conversion Factors and Dimensional Analysis
The unit...
Conversion Factors and Dimensional Analysis
The unit...
65.0K
01:27Dimensional Analysis
682
Dimensional analysis is a valuable technique in fluid mechanics for simplifying complex problems by reducing them into dimensionless groups. These groups capture the essential relationships between the variables involved, allowing researchers and engineers to analyze fluid flow without dealing with each variable individually. This approach reduces the number of independent variables, allowing for easier analysis and better understanding of physical phenomena.
In fluid mechanics, dimensional...
In fluid mechanics, dimensional...
682
01:23Dimensional Analysis
2.2K
Dimensional analysis is a powerful tool that is used in physics and engineering to understand and predict the behavior of physical systems. The basic idea behind dimensional analysis is to express physical quantities in terms of fundamental dimensions such as the mass, length, and time. Derived dimensions like the velocity, acceleration, and force are derived from the combinations of these fundamental dimensions.
Dimensional analysis allows us to analyze and compare physical quantities on a...
Dimensional analysis allows us to analyze and compare physical quantities on a...
2.2K
02:19Dimensional Analysis
24.5K
The concept of dimension is important because every mathematical equation linking physical quantities must be dimensionally consistent, implying that mathematical equations must meet the following two rules. The first rule is that, in an equation, the expressions on each side of the equal sign must have the same dimensions. This is fairly intuitive since we can only add or subtract quantities of the same type (dimension). The second rule states that, in an equation, the arguments of any of the...
24.5K
02:27Predicting Products: SN1 vs. SN2
17.4K
Nucleophilic substitution reactions of alkyl halides can proceed via an SN1 or an SN2 mechanism. While in SN2 reactions, the nucleophile attacks the substrate simultaneously as the leaving group departs, in SN1 reactions, the substrate first dissociates to give the carbocation intermediate. Various factors such as the structure of the substrate, the strength of the nucleophile, and the nature of the solvent promote one mechanism over the other.
With increased substitution on the alkyl halide,...
With increased substitution on the alkyl halide,...
17.4K