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Related Experiment Videos

Computer tomography of the spinal canal using metrizamide.

I Isherwood1, R A Fawcitt, W St Clair Forbes

  • 1Department of Diagnostic Radiology, University of Manchester, England.

Acta Radiologica. Supplementum
|January 1, 1977
PubMed
Summary

Metrizamide contrast medium is essential for visualizing the spinal cord and its pathologies. It distributes within the spinal cord

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Area of Science:

  • Neuroradiology
  • Medical Imaging
  • Pharmacokinetics

Background:

  • Metrizamide (Amipaque) is a water-soluble contrast agent used in neuroradiology.
  • Understanding its distribution and behavior in the spinal canal is crucial for diagnostic accuracy.

Purpose of the Study:

  • To investigate the distribution, flow, and dilution of metrizamide in the spinal canal and spinal cord.
  • To assess the impact of metrizamide on CT attenuation values of the spinal cord.

Main Methods:

  • Whole body computed tomography (CT) using EMI CT 5000.
  • Lumbar injection of 10 ml metrizamide (170 mg I/ml) in eleven patients.
  • Modeling of spectral filtering effects on spinal cord attenuation values.

Main Results:

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  • Metrizamide is necessary for demonstrating the neural axis and associated pathologies.
  • The contrast medium enters the extracellular space of the spinal cord within the first hour.
  • Equilibrium in the subarachnoid space and spinal cord is achieved between 3 to 6 hours.
  • Potential concentration in a second, possibly intracellular, compartment observed from 3 to 6 hours.
  • Spectral filtering effects are not significant at expected dilutions.

Conclusions:

  • Metrizamide's distribution pattern aids in visualizing spinal cord structures and pathologies.
  • The contrast medium's pharmacokinetic behavior is characterized by extracellular and potential intracellular distribution.
  • CT imaging with metrizamide is reliable, with minimal artifact from spectral filtering.