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Correlation Between Oral Lichen Planus and Thyroid Disease in China: A Case-Control Study
Tingting Zhou1, Dan Li1, Qianming Chen2
1Department of Oral Medicine, Peking University School and Hospital of Stomatology, Beijing, China.
Frontiers in Endocrinology
|July 4, 2018
Summary
This study found a significant link between oral lichen planus (OLP) and thyroid diseases, particularly Hashimoto's thyroiditis and thyroid nodules, in Chinese patients. Further research is needed to understand the underlying mechanisms.
Area of Science:
- Oral medicine
- Endocrinology
- Immunology
Background:
- Oral lichen planus (OLP) and thyroid diseases are increasingly recognized as potentially related conditions.
- Previous research suggests an association, prompting further investigation into this link.
Purpose of the Study:
- To investigate the correlation between oral lichen planus (OLP) and various thyroid diseases in Chinese patients.
- To evaluate the prevalence of thyroid conditions in individuals with OLP and oral lichenoid lesions (OLLs).
Main Methods:
- A case-control study involving 192 OLP patients, 123 OLL patients, and 162 controls.
- Participants underwent thyroid function screening and ultrasound; demographic data were matched.
- Logistic regression analysis was used to determine odds ratios for associations between OLP/OLL and thyroid diseases.
Main Results:
- The prevalence of thyroid diseases was significantly higher in OLP (72.4%) and OLL (68.3%) groups compared to controls (49.4%).
- A significant association was found between OLP and Hashimoto's thyroiditis (OR 3.16) and thyroid nodules (OR 2.31).
- Oral lichenoid lesions (OLLs) also showed a significant association with Hashimoto's thyroiditis (OR 2.09).
Conclusions:
- A close relationship exists between oral lichen planus (OLP)/oral lichenoid lesions (OLLs) and Hashimoto's thyroiditis (HT) and thyroid nodules in the Chinese population.
- The findings highlight the importance of considering thyroid health in patients with OLP and OLL.
- Further research is recommended to elucidate the specific mechanisms underlying this observed association.
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