Related Experiment Video
Updated: Feb 8, 2026
12:26
In Vivo Direct Reprogramming of Resident Glial Cells into Interneurons by Intracerebral Injection of Viral Vectors
Published on: June 17, 2019
10.1K
Metabolic Reprogramming and Longevity of Tissue-Resident Memory T Cells
Youdong Pan1, Thomas S Kupper1
1Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Frontiers in Immunology
|July 4, 2018
Summary
Tissue-resident memory T cells (TRM) are crucial for immediate immune defense. This review highlights their unique metabolic programming and potential therapeutic targeting for TRM-mediated diseases.
Area of Science:
- Immunology
- Cellular Metabolism
- Tissue-resident Memory T cells
Background:
- Tissue-resident memory T cells (TRM) provide long-term immunity within tissues.
- TRM are vital for defense against infections and in autoimmune diseases.
- TRM possess distinct metabolic profiles compared to other T cell subsets.
Purpose of the Study:
- To review recent advancements in understanding TRM metabolic programming.
- To explore the potential of targeting TRM metabolism for therapeutic interventions.
Main Methods:
- Literature review of studies on TRM metabolism.
- Analysis of gene expression profiles and metabolic pathways in TRM.
Main Results:
- TRM exhibit unique gene expression related to cellular metabolism.
- Skin CD8+ TRM utilize fatty acid oxidation for survival and function.
- Metabolic differences distinguish TRM from naive, central memory, and effector memory T cells.
Conclusions:
- TRM metabolic programming is critical for their longevity and function.
- Targeting TRM metabolic pathways offers a promising therapeutic strategy for TRM-mediated diseases.
Related Concept Videos
01:29Somatic to iPS Cell Reprogramming
2.7K
Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
2.7K
00:52What is Metabolism?
132.0K
Overview
132.0K
02:01Plant Cells and Tissues
65.8K
Plant tissues are collections of similar cells performing related functions. Different plant tissues will have their own specialized roles and can be combined with other tissues to form organs such as flowers, fruit, stem, and leaves. Two major types of plant tissue include meristematic and permanent tissue.
65.8K
01:23System of Memory
7.4K
Memory is categorized into three major systems: sensory memory, short-term memory (STM), and long-term memory (LTM). These systems differ in their capacity and the duration for which they can hold information. Sensory memory captures raw sensory input from the environment, holding it for just a few seconds or less. For example, on hearing a brief, loud sound, like a car horn honking, the sound seems to linger in the mind for a moment even after it stops. This is an instance of sensory memory...
7.4K
01:24Working Memory
902
Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this...
902
01:05Noncompartmental Analysis: Mean Residence Time
611
According to statistical moment theory, mean residence time (MRT) is an important measure in pharmacokinetics. MRT can be defined as the expected mean of a probability density function distribution. It provides valuable insights into drug disposition in the body.
After the administration of a drug through intravenous bolus injection, the drug molecules are distributed throughout the body and remain there for varying periods. The MRT represents the average time these drug molecules stay in the...
After the administration of a drug through intravenous bolus injection, the drug molecules are distributed throughout the body and remain there for varying periods. The MRT represents the average time these drug molecules stay in the...
611