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Related Experiment Video

Updated: Feb 8, 2026

Translational Rabbit Model of Chronic Cardiac Pacing

Translational Rabbit Model of Chronic Cardiac Pacing

Published on: January 6, 2023

Pacing for Vasovagal Syncope.

Rakesh Gopinathannair¹, Benjamin C Salgado¹, Brian Olshansky²

¹Division of Cardiovascular Medicine, University of Louisville Louisville, USA.

Arrhythmia & Electrophysiology Review

|July 4, 2018

Summary

This summary is machine-generated.

Permanent pacemaker implantation, particularly DDD pacing with closed-loop stimulation, may benefit select patients experiencing recurrent vasovagal syncope (VVS) when conservative treatments fail.

Keywords:

Syncope asystole closed loop stimulation pacing rate drop response vasovagal syncope

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Area of Science:

Cardiology
Autonomic Nervous System

Background:

Vasovagal syncope (VVS) is a common autonomic reflex causing bradycardia and/or hypotension.
Recurrent VVS can be debilitating, with limited effective medical therapies.
The role of permanent pacing in VVS management is debated.

Purpose of the Study:

To evaluate the potential benefits of permanent pacing in managing recurrent vasovagal syncope.
To identify optimal pacing strategies for VVS prevention.

Main Methods:

Review of available data on VVS and permanent pacing.
Analysis of the temporal association between bradycardia and syncope.
Consideration of pacing parameters like mode, rate, and algorithm.

Main Results:

DDD pacing with closed-loop stimulation shows promise for preventing recurrent VVS.
The timing and type of pacing relative to the vasovagal reflex are critical factors.
Permanent pacing may be beneficial for select VVS patients.

Conclusions:

Permanent pacing, especially DDD pacing with closed-loop stimulation, is a viable option for managing refractory VVS.
Further research is needed to fully elucidate optimal pacing strategies.
Pacing offers a potential role in managing specific VVS cases.