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Updated: Feb 8, 2026

Assessing Specificity of Anticancer Drugs In Vitro
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Published on: March 23, 2016

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Non-Coding RNAs and Resistance to Anticancer Drugs in Gastrointestinal Tumors

Jens C Hahne1, Nicola Valeri1,2

  • 1Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom.

Frontiers in Oncology
|July 4, 2018
PubMed

Insights

Non-coding RNAs, including long non-coding RNAs and microRNAs, drive cancer drug resistance by regulating key genes and pathways. Understanding these roles is crucial for overcoming treatment failure in gastrointestinal cancers.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Non-coding RNAs (ncRNAs) are critical regulators of gene expression.
  • Dysregulated ncRNAs, particularly long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), are implicated in various pathologies, including cancer.
  • ncRNAs play a significant role in the development of resistance to anticancer therapies.

Purpose of the Study:

  • To review the multifaceted roles of ncRNAs in mediating drug resistance in gastrointestinal cancers.
  • To elucidate the specific mechanisms by which ncRNAs contribute to therapeutic resistance.

Main Methods:

  • Literature review of studies on non-coding RNAs and cancer drug resistance.
  • Analysis of ncRNA involvement in mechanisms like drug transport, metabolism, cell cycle, apoptosis, cancer stem cells, and EMT.
  • Focus on gastrointestinal cancer contexts.

Main Results:

  • ncRNAs regulate genes involved in drug resistance.
  • They influence intracellular drug concentrations and activate alternative signaling pathways.
  • ncRNAs can prevent apoptosis, promote epithelial-mesenchymal transition (EMT), and mediate non-cell autonomous resistance.

Conclusions:

  • Non-coding RNAs are key players in diverse drug resistance mechanisms within gastrointestinal cancers.
  • Targeting ncRNAs presents a potential strategy to overcome therapeutic resistance.
  • Further research into ncRNA functions can inform novel cancer treatment approaches.
Keywords:
anticancer drugscancer therapygastrointestinal tumorlncRNAmicroRNAnon-coding RNAresistance

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