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Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
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Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

Published on: December 11, 2017

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Acquired resistance to cancer immunotherapy

Arianna Draghi1, Christopher Aled Chamberlain1, Andrew Furness2

  • 1Center for Cancer Immune Therapy (CCIT), Department of Hematology, Herlev Hospital, University of Copenhagen, Herlev Ringvej 75, 2730, Herlev, Denmark.

Seminars in Immunopathology
|July 4, 2018
PubMed

Insights

Cancer immunotherapy shows promise, but resistance is a challenge. This review explores tumor factors and strategies to overcome immunotherapy resistance for better patient outcomes.

Area of Science:

  • Oncology
  • Immunology
  • Cancer Research

Background:

  • Cancer immunotherapy has achieved significant clinical success in various cancer types.
  • However, many patients develop resistance to these treatments, leading to disease progression.

Purpose of the Study:

  • To review the current understanding of tumor-intrinsic and tumor-extrinsic factors contributing to cancer immunotherapy resistance.
  • To discuss existing and potential therapeutic strategies to overcome this resistance.

Main Methods:

  • Literature review of recent advances in cancer immunotherapy resistance.
  • Synthesis of knowledge on mechanisms of resistance.
  • Analysis of therapeutic strategies targeting resistance pathways.

Main Results:

  • Identified key tumor-intrinsic factors (e.g., genetic mutations, tumor microenvironment) influencing immunotherapy response.
  • Highlighted crucial tumor-extrinsic factors (e.g., systemic immunity, microbiome) impacting treatment efficacy.
  • Summarized current therapeutic approaches and future directions for overcoming resistance.

Conclusions:

  • Understanding the multifaceted nature of resistance is critical for improving immunotherapy efficacy.
  • Targeting both tumor-intrinsic and extrinsic factors offers promising avenues for novel therapeutic development.
  • Overcoming resistance is a high scientific priority to enhance clinical outcomes in cancer patients.
Keywords:
Acquired resistanceCancer immunotherapyCheckpoint inhibitorsImmune escapeImmune evasion

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